Archive for the ‘Drugs For Pain’ Category

Arthritis pain: Do’s and don’ts

Sunday, December 28th, 2008

Arthritis pain can be frustrating. And so is sorting through your pain relief options. To help you figure out the best means of relieving your arthritis pain, Gene Hunder, M.D., an emeritus rheumatology specialist at Mayo Clinic, Rochester, Minn., and a professor of medicine at Mayo Clinic College of Medicine, answers some commonly asked questions about arthritis pain. Dr. Hunder is an authority on rheumatology and is editor-in-chief of the book “Mayo Clinic Straight Talk On Arthritis.”

Will physical activity make your arthritis pain worse?

If you already have joint damage, you can make your arthritis pain worse with activities that are stressful to your joints or that require repetitive motion.

However, if you have only minimal joint damage and most of your symptoms are related to the ligaments, tendons and muscles surrounding your joints — not the joints themselves — a gentle exercise program could improve your arthritis pain. Be sure to include stretching and muscle strengthening in your exercise program.

Work with your doctor to determine the right solution and exercise program for your specific situation. Arthritis varies a great deal from one person to another. Ask your doctor to carefully define the type and extent of your arthritis. Use that information to decide the best approach to your hobbies and activities.

What sorts of activities should generally be avoided, and what types of activities are good for most people with arthritis pain?

Activities that put sudden pressure or stress on involved joints — such as running and playing tennis — are likely to make the symptoms of arthritis in the lower extremities worse and may cause increased swelling and inflammation. Activities that are likely to help include exercises that strengthen your muscles, protect your joints, and reduce stress and joint damage. For example, strengthening the muscles on the front and back of your thigh (quadriceps and hamstrings) helps protect your knee and hip joints. Your doctor might be able to teach you some exercises to increase your muscle strength without abusing your joints.

Do what you can to stay physically active while taking into consideration the condition of your joints. For example, you may be able to walk a mile or more at a comfortable pace with well-fitting, cushioned shoes. But you probably have to give up on high-impact activities — for instance sports such as soccer that involve running — which put a lot of stress on many different joints. If your joints are too painful or damaged to allow an activity such as walking, then swimming or other water exercise may be a better choice for keeping you active and getting toned.

How can you reduce the stiffness and pain that come from sitting for a long time?

Many people with arthritis experience stiffness after sitting or resting, especially if they’ve used their joints actively before periods of inactivity. Most people with rheumatoid arthritis have stiffness after rest, such as in the morning. These are common symptoms of arthritis. Movement will tend to diminish some of the symptoms.

If you must sit for a long time, adjust your position often to prevent or lessen stiffness. For example, turn your head at different angles, shift the position of your arms, and bend and stretch out your legs. Such slight movements may help prevent excessive stiffness. Many times the stiffness may be worse for a few days after you’ve used your joint strenuously.

When does arthritis pain indicate you should call your doctor?

If new pain develops or you have persistent symptoms — lasting more than several days — call your doctor. Treatment is often more effective when arthritis symptoms are caught early. If you have symptoms that you know are from overdoing it and they disappear in a few days, you probably don’t need to call your doctor.

What medications are best for arthritis pain relief?

The good news is that there are now many medications available for arthritis. Most are relatively safe and well tolerated, but no medication is completely free of possible side effects. If your symptoms are a regular problem, you need professional advice from your doctor about what medications to take and how much.

If your pain is present only occasionally and follows some unusual activity, you could try one or two acetaminophen tablets (Tylenol, others), which are sold over-the-counter. Many such preparations are available. Ordinarily, all work equally well. Some people prefer aspirin instead. If you have a history of peptic ulcer disease, bleeding, asthma or allergies, talk to your doctor before taking aspirin or a drug such as ibuprofen.

If your symptoms are prolonged and are related to activities that you don’t participate in all of the time, nonsteroidal anti-inflammatory drugs (NSAIDs) — such as ibuprofen (Advil, Motrin, others) and naproxen (Aleve, others) — may bring relief. These drugs can be purchased without a prescription. Weekend tennis players, gardeners and others with mild osteoarthritis can overcome some of the disagreeable stiffness by taking only one or two over-the-counter NSAID tablets for one or two days after the activity, or even before the activity.

If your symptoms are more prolonged and severe, it may mean that the joint involvement is more advanced, and you may need larger doses of drugs on a regular basis. Until recently we prescribed COX-2 inhibitors for people who had stomach pain or other side effects from other NSAIDs. However, recent data suggest that COX-2 drugs may cause heart problems in some people. Consult your doctor if you aren’t getting sufficient pain relief from your medications.

Are alternative treatments helpful for arthritis pain?

This question raises complex issues, and there’s no short and easy answer that applies to all alternative arthritis treatments. Even the definition of alternative treatments varies from one source to another. For example, heat, massage and stretching — which help relieve arthritis symptoms for many people — have been listed as alternative treatment by some, but in reality these have been standard practice for many years.

The best treatments of this type are straightforward and have your doctor’s or physical therapist’s stamp of approval. Some activities may be more interesting and fun to do, such as tai chi. A good rule of thumb: If it keeps you active, then it’s helpful.

The problem with many alternative preparations is that they haven’t been adequately studied. In most people, arthritis symptoms vary from day to day. So if you take an herbal preparation, for example, on a day that you might have felt better anyway, you may become convinced that the herb made you better. In arthritis treatment studies, as many as 30 percent of people taking an inactive substance (placebo) improve, at least temporarily.

Finally, quality standards for over-the-counter alternative drugs don’t exist. Research shows that there’s a great variation in the amount of active substance in different brands and even different lots of the same brand. This alone may be reason to avoid them.

Finding an effective and safe medication for arthritis pain is a complex task that may take years. Trying to shortcut standard practices may lead to harmful effects and wasted money, time and effort.

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Hydrochlorothiazide and valsartan

Tuesday, September 9th, 2008

What is hydrochlorothiazide and valsartan?

Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Valsartan is in a group of drugs called angiotensin II receptor antagonists. Valsartan keeps blood vessels from narrowing, which lowers blood pressure improves blood flow.

The combination of hydrochlorothiazide and valsartan is used to treat high blood pressure (hypertension).

Hydrochlorothiazide and valsartan may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about hydrochlorothiazide and valsartan?

Do not use this medication if you are allergic to hydrochlorothiazide or valsartan, or if you are unable to urinate.

Do not use this medication without telling your doctor if you are pregnant. Valsartan may cause injury and even death to the unborn baby if you take it during the second and third trimesters of pregnancy. Use an effective form of birth control. Stop using this medication and tell your doctor right away if you become pregnant during treatment.

Before using hydrochlorothiazide and valsartan, tell your doctor if you have congestive heart failure, kidney or liver disease, asthma, low or high blood levels of potassium, gout, lupus, diabetes, or an allergy to sulfa drugs.

Avoid drinking alcohol. It can lower your blood pressure and may increase some of the side effects of hydrochlorothiazide and valsartan.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor’s instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Do not use potassium supplements or salt substitutes while you are taking hydrochlorothiazide and valsartan, unless your doctor has told you to.

What should I discuss with my healthcare provider before taking hydrochlorothiazide and valsartan?

Do not use this medication if you are allergic to hydrochlorothiazide or valsartan (Cozaar), or if you are unable to urinate.

Before using hydrochlorothiazide and valsartan, tell your doctor if you have:

  • kidney disease;
  • liver disease;
  • congestive heart failure;
  • asthma or allergies;
  • low or high levels of magnesium or potassium in your blood;
  • gout;
  • lupus;
  • diabetes; or
  • an allergy to sulfa drugs.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take hydrochlorothiazide and valsartan.

FDA pregnancy category D. This medication can cause harm to an unborn baby. Do not use this medication without telling your doctor if you are pregnant. Valsartan may cause injury and even death to the unborn baby if you take it during the second and third trimesters of pregnancy. Use an effective form of birth control. Stop using this medication and tell your doctor right away if you become pregnant during treatment.

It is not known whether hydrochlorothiazide and valsartan passes into breast milk. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

How should I take hydrochlorothiazide and valsartan?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Take this medication with a full glass (8 ounces) of water.

To be sure this medication is helping your condition, your blood pressure will need to be checked on a regular basis. Do not miss any scheduled appointments.

Hydrochlorothiazide can interfere with the results of a thyroid test. Tell any doctor who treats you that you are using this medication.

If you are being treated for high blood pressure, keep using this medication even if you feel fine. High blood pressure often has no symptoms.

Store hydrochlorothiazide and valsartan at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include fast or slow heartbeat, feeling light-headed, or fainting.

What should I avoid while taking hydrochlorothiazide and valsartan?

Avoid drinking alcohol. It can lower your blood pressure and may increase some of the side effects of hydrochlorothiazide and valsartan.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor’s instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Do not use potassium supplements or salt substitutes while you are taking hydrochlorothiazide and valsartan, unless your doctor has told you to.

What are the possible side effects of hydrochlorothiazide and valsartan?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have a serious side effect such as:

  • feeling light-headed, fainting;
  • swelling, rapid weight gain;
  • fast or pounding heartbeats;
  • urinating less than usual, or not at all;
  • jaundice (yellowing of the skin or eyes); or
  • dry mouth, increased thirst, drowsiness, restless feeling, confusion, nausea, vomiting, increased urination, muscle pain or weakness, fast heart rate, feeling light-headed, fainting, or seizure (convulsions).

Less serious side effects may include:

  • stomach pain, nausea, diarrhea;
  • back pain;
  • headache, tired feeling, dizziness;
  • skin rash;
  • stuffy nose, sore throat; or
  • dry cough.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

What other drugs will affect hydrochlorothiazide and valsartan?

Before taking hydrochlorothiazide and valsartan, tell your doctor if you are using any of the following drugs:

  • any other blood pressure medications;
  • steroids (prednisone and others);
  • lithium (Eskalith, Lithobid);
  • celecoxib (Celebrex) or valdecoxib (Bextra);
  • cholestyramine (Prevalite, Questran) or colestipol (Colestid);
  • insulin or diabetes medications you take by mouth;
  • rifampin (Rifadin, Rimactane, Rifater);
  • a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Luminal, Solfoton);
  • any other diuretics, such as amiloride (Midamor), bumetanide (Bumex), chlorthalidone (Hygroton, Thalitone), ethacrynic acid (Edecrin), furosemide (Lasix), hydrochlorothiazide (HCTZ, HydroDiuril), indapamide (Lozol), metolazone (Mykrox, Zarxolyn), spironolactone (Aldactone), triamterene (Dyrenium, Maxzide, Dyazide), torsemide (Demadex), and others;
  • aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Motrin, Advil), diclofenac (Voltaren), diflunisal (Dolobid), etodolac (Lodine), flurbiprofen (Ansaid), indomethacin (Indocin), ketoprofen (Orudis), ketorolac (Toradol), mefenamic acid (Ponstel), meloxicam (Mobic), nabumetone (Relafen), naproxen (Aleve, Naprosyn), piroxicam (Feldene), and others;
  • a muscle relaxer such as baclofen (Lioresal), carisoprodol (Soma), cyclobenzaprine (Flexeril), dantrolene (Dantrium), metaxalone (Skelaxin), or methocarbamol (Robaxin), orphenadrine (Norflex), or tizanidine (Zanaflex);
  • a narcotic medication such as hydrocodone (Lortab, Vicodin), hydromorphone (Dilaudid, Palladone), levorphanol (Levo-Dromoran), meperidine (Demerol), methadone (Methadose), morphine (Kadian, MS Contin), oxycodone (OxyContin), oxymorphone (Numorphan), or propoxyphene (Darvon, Darvocet).

This list is not complete and there may be other drugs not listed that can affect hydrochlorothiazide and valsartan. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about hydrochlorothiazide and valsartan.

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Hydrochlorothiazide and telmisartan

Tuesday, September 2nd, 2008

What are hydrochlorothiazide and telmisartan?

Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Telmisartan is in a group of drugs called angiotensin II receptor antagonists. Telmisartan keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.

The combination of hydrochlorothiazide and telmisartan is used to treat high blood pressure (hypertension).

Hydrochlorothiazide and telmisartan may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about hydrochlorothiazide and telmisartan?

Do not use this medication without telling your doctor if you are pregnant. Hydrochlorothiazide and telmisartan may cause injury and even death to the unborn baby if you take it during the second and third trimesters of pregnancy. Use an effective form of birth control. Stop using this medication and tell your doctor right away if you become pregnant during treatment.

Avoid drinking alcohol. It can lower your blood pressure and may increase some of the side effects of hydrochlorothiazide and telmisartan.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor’s instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Do not use potassium supplements or salt substitutes while you are taking hydrochlorothiazide and telmisartan, unless your doctor has told you to.

Who should not take hydrochlorothiazide and telmisartan?

Do not use this medication if you are allergic to telmisartan (Micardis) or hydrochlorothiazide (Carozide, Diaqua, Ezide HCTZ, HydroDiuril, Microzide), or if you:

  • are unable to urinate; or
  • are allergic to sulfa drugs.

Before using hydrochlorothiazide and telmisartan, tell your doctor if you are allergic to any drugs, or if you have:

  • kidney disease;
  • liver disease;
  • congestive heart failure;
  • asthma or allergies;
  • low or high levels of magnesium or potassium in your blood;
  • gout;
  • systemic lupus erythematosus (SLE); or
  • diabetes.

If you have any of these conditions, you may not be able to use hydrochlorothiazide and telmisartan, or you may need a dosage adjustment or special tests during treatment.

FDA pregnancy category D. This medication can cause harm to an unborn baby. Hydrochlorothiazide and telmisartan may cause injury and even death to the unborn baby if you take it during the second and third trimesters of pregnancy. Do not use hydrochlorothiazide and telmisartan without your doctor’s consent if you are pregnant. Use an effective form of birth control. Stop using this medication and tell your doctor right away if you become pregnant during treatment.

It is not known whether hydrochlorothiazide and telmisartan passes into breast milk. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

How should I take hydrochlorothiazide and telmisartan?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Take this medication with a full glass (8 ounces) of water.

To be sure this medication is helping your condition, your blood pressure will need to be checked on a regular basis. Do not miss any scheduled visits to your doctor.

Hydrochlorothiazide can interfere with the results of a thyroid test. Tell any doctor who treats you that you are using this medication.

If you are being treated for high blood pressure, keep using this medication even if you feel fine. High blood pressure often has no symptoms.

Store hydrochlorothiazide and telmisartan at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Symptoms of a hydrochlorothiazide and telmisartan overdose may include fast or slow heartbeat, feeling light-headed, or fainting.

What should I avoid while taking hydrochlorothiazide and telmisartan?

Avoid drinking alcohol. It can lower your blood pressure and may increase some of the side effects of hydrochlorothiazide and telmisartan.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor’s instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Do not use potassium supplements or salt substitutes while you are taking hydrochlorothiazide and telmisartan, unless your doctor has told you to.

What are the possible side effects of hydrochlorothiazide and telmisartan?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

  • feeling light-headed, fainting;
  • swelling, rapid weight gain;
  • fast or pounding heartbeats;
  • urinating less than usual, or not at all;
  • jaundice (yellowing of the skin or eyes); or
  • dry mouth, increased thirst, drowsiness, restless feeling, confusion, nausea, vomiting, increased urination, muscle pain or weakness, fast heart rate, feeling light-headed, fainting, or seizure (convulsions).

Continue using the medication and talk with your doctor if you have any of these less serious side effects:

  • stomach pain, nausea, diarrhea;
  • back pain;
  • headache, tired feeling, dizziness;
  • skin rash;
  • stuffy nose, sore throat; or
  • dry cough.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect hydrochlorothiazide and telmisartan?

Before taking hydrochlorothiazide and telmisartan, tell your doctor if you are using any of the following drugs:

  • any other blood pressure medications;
  • digoxin (digitalis, Lanoxin, Lanoxicaps);
  • a blood thinner such as warfarin (Coumadin);
  • steroids (prednisone and others);
  • lithium (Eskalith, Lithobid);
  • cholestyramine (Prevalite, Questran) or colestipol (Colestid);
  • insulin or diabetes medications you take by mouth;
  • a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Luminal, Solfoton);
  • any other diuretics, such as amiloride (Midamor), bumetanide (Bumex), chlorthalidone (Hygroton, Thalitone), ethacrynic acid (Edecrin), furosemide (Lasix), hydrochlorothiazide (HCTZ, HydroDiuril), indapamide (Lozol), metolazone (Mykrox, Zarxolyn), spironolactone (Aldactone), triamterene (Dyrenium, Maxzide, Dyazide), torsemide (Demadex), and others;
  • aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Motrin, Advil), diclofenac (Voltaren), diflunisal (Dolobid), etodolac (Lodine), flurbiprofen (Ansaid), indomethacin (Indocin), ketoprofen (Orudis), ketorolac (Toradol), mefenamic acid (Ponstel), meloxicam (Mobic), nabumetone (Relafen), naproxen (Aleve, Naprosyn), piroxicam (Feldene), and others;
  • a muscle relaxer such as baclofen (Lioresal), carisoprodol (Soma), cyclobenzaprine (Flexeril), dantrolene (Dantrium), metaxalone (Skelaxin), or methocarbamol (Robaxin), orphenadrine (Norflex), or tizanidine (Zanaflex);
  • a narcotic medication such as hydrocodone (Lortab, Vicodin), hydromorphone (Dilaudid, Palladone), levorphanol (Levo-Dromoran), meperidine (Demerol), methadone (Methadose), morphine (Kadian, MS Contin), oxycodone (OxyContin), oxymorphone (Numorphan), or propoxyphene (Darvon, Darvocet).

If you are using any of these drugs, you may not be able to use hydrochlorothiazide and telmisartan, or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect hydrochlorothiazide and telmisartan. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist has information about hydrochlorothiazide and telmisartan written for health professionals that you may read.

What does my medication look like?

Hydrochlorothiazide and telmisartan is available with a prescription under the brand name Micardis HCT. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

  • Micardis HCT 12.5 mg/40 mg–red and white layered, oblong-shaped tablets
  • Micardis HCT 12.5 mg/80 mg–red and white layered, oblong-shaped tablets
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Candesartan and hydrochlorothiazide

Tuesday, August 26th, 2008

What is candesartan and hydrochlorothiazide?

Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Candesartan is in a group of drugs called angiotensin II receptor antagonists. Candesartan keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.

The combination of candesartan and hydrochlorothiazide is used to treat high blood pressure (hypertension).

Candesartan and hydrochlorothiazide may also be used for purposes other than those listed in this medication guide.

Who should not take candesartan and hydrochlorothiazide?

Do not use this medication if you are allergic to candesartan or hydrochlorothiazide (Carozide, Diaqua, Ezide HCTZ, HydroDiuril, Microzide, and others), or if you:

  • are unable to urinate; or
  • are allergic to sulfa drugs.

Before using candesartan and hydrochlorothiazide, tell your doctor if you are allergic to any drugs, or if you have:

  • kidney disease;
  • liver disease;
  • congestive heart failure;
  • low or high levels of potassium in your blood;
  • asthma or allergies;
  • high cholesterol or triglyceride levels;
  • gout;
  • lupus; or
  • diabetes.

If you have any of these conditions, you may not be able to use candesartan and hydrochlorothiazide, or you may need a dosage adjustment or special tests during treatment.

FDA pregnancy category D. This medication can cause harm to an unborn baby. Candesartan and hydrochlorothiazide may cause injury and even death to the unborn baby if you take it during the second and third trimesters of pregnancy. Do not use candesartan and hydrochlorothiazide without your doctor’s consent if you are pregnant. Use an effective form of birth control. Stop using this medication and tell your doctor right away if you become pregnant during treatment.

It is not known whether candesartan and hydrochlorothiazide passes into breast milk. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

How should I take candesartan and hydrochlorothiazide?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Take this medication with a full glass (8 ounces) of water.

To be sure this medication is helping your condition, your blood pressure will need to be checked on a regular basis. Your kidney function may also need to be tested. Do not miss any scheduled visits to your doctor.

Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking this medication, which can lead to severely low blood pressure or a serious electrolyte imbalance.

Hydrochlorothiazide can interfere with the results of a thyroid test. Tell any doctor who treats you that you are using this medication.

It may take up to 4 weeks for this medication to control your blood pressure. Keep using this medication even if you feel fine. High blood pressure often has no symptoms.

If you need to have any type of surgery, tell the surgeon ahead of time that you are using candesartan and hydrochlorothiazide. You may need to stop using the medicine for a short time.

Store candesartan and hydrochlorothiazide at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Symptoms of a candesartan and hydrochlorothiazide overdose may include fast or slow heartbeat, feeling light-headed, or fainting.

What should I avoid while taking candesartan and hydrochlorothiazide?

Candesartan and hydrochlorothiazide can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid drinking alcohol. It can lower your blood pressure and may increase some of the side effects of candesartan and hydrochlorothiazide.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor’s instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Do not use potassium supplements or salt substitutes while you are taking candesartan and hydrochlorothiazide, unless your doctor has told you to.

What are the possible side effects of candesartan and hydrochlorothiazide?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

  • feeling light-headed, fainting;
  • chest pain, feeling short of breath, even with mild exertion;
  • fever;
  • swelling, rapid weight gain;
  • urinating more or less than usual, or not at all;
  • jaundice (yellowing of the skin or eyes); or
  • dry mouth, increased thirst, drowsiness, restless feeling, confusion, nausea, vomiting, increased urination, muscle pain or weakness, fast heart rate, feeling light-headed, fainting, or seizure (convulsions).

Continue using the medication and talk with your doctor if you have any of these less serious side effects:

  • stomach pain;
  • back pain;
  • dizziness, drowziness;
  • headache;
  • runny or stuffy nose, sore throat; or
  • dry cough.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect candesartan and hydrochlorothiazide?

Before taking candesartan and hydrochlorothiazide, tell your doctor if you are using any of the following drugs:

  • any other blood pressure medications;
  • steroids (prednisone and others);
  • lithium (Eskalith, Lithobid);
  • cholestyramine (Prevalite, Questran) or colestipol (Colestid);
  • insulin or diabetes medicine you take by mouth;
  • a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Luminal, Solfoton);
  • any other diuretics, such as amiloride (Midamor), bumetanide (Bumex), chlorthalidone (Hygroton, Thalitone), ethacrynic acid (Edecrin), furosemide (Lasix), hydrochlorothiazide (HCTZ, HydroDiuril), indapamide (Lozol), metolazone (Mykrox, Zarxolyn), spironolactone (Aldactone), triamterene (Dyrenium, Maxzide, Dyazide), torsemide (Demadex), and others;
  • aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Motrin, Advil), diclofenac (Voltaren), diflunisal (Dolobid), etodolac (Lodine), flurbiprofen (Ansaid), indomethacin (Indocin), ketoprofen (Orudis), ketorolac (Toradol), mefenamic acid (Ponstel), meloxicam (Mobic), nabumetone (Relafen), naproxen (Aleve, Naprosyn), piroxicam (Feldene), and others;
  • a muscle relaxer such as baclofen (Lioresal), carisoprodol (Soma), cyclobenzaprine (Flexeril), dantrolene (Dantrium), metaxalone (Skelaxin), or methocarbamol (Robaxin), orphenadrine (Norflex), or tizanidine (Zanaflex); or
  • a narcotic medication such as hydrocodone (Lortab, Vicodin), hydromorphone (Dilaudid, Palladone), levorphanol (Levo-Dromoran), meperidine (Demerol), methadone (Methadose), morphine (Kadian, MS Contin), oxycodone (OxyContin), oxymorphone (Numorphan), or propoxyphene (Darvon, Darvocet).

If you are using any of these drugs, you may not be able to use candesartan and hydrochlorothiazide, or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect candesartan and hydrochlorothiazide. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist has information about candesartan and hydrochlorothiazide written for health professionals that you may read.

What does my medication look like?

Candesartan and hydrochlorothiazide is available with a prescription under the brand name Atacand. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

  • Atacand HCT 16-12.5 (16 mg of candesartan and 12.5 mg of hydrochlorothiazide)–peach, oval tablets
  • Atacand HCT 32-12.5 (32 mg of candesartan and 12.5 mg of hydrochlorothiazide)–yellow, oval tablets
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Aspirin and carisoprodol

Wednesday, August 20th, 2008

What is aspirin and carisoprodol?

Aspirin is in a class of drugs called salicylates. Aspirin works by reducing substances in the body that cause pain and inflammation. It is used to reduce pain, inflammation, and fever.

Carisoprodol is a muscle relaxant. It works by blocking nerve impulses (or pain sensations) that are sent to the brain.

The combination of aspirin and carisoprodol is used, along with rest and physical therapy, to treat injuries and other painful muscular conditions.

Aspirin and carisoprodol may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about aspirin and carisoprodol?

Use caution when driving, operating machinery, or performing other hazardous activities. Aspirin and carisoprodol may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking aspirin and carisoprodol. Also, in combination with aspirin, alcohol can be damaging to the stomach.

Watch for bloody, black, or tarry stools or bloody vomit. This could indicate damage to the stomach.

Do not take more of this medication than is prescribed. If the pain is not being adequately treated, talk to your doctor.

What should I discuss with my healthcare provider before taking aspirin and carisoprodol?

Do not take aspirin and carisoprodol without first talking to your doctor if you have acute intermittent porphyria.

Before taking this medication, tell your doctor if you have

  • kidney disease,
  • liver disease,
  • a stomach or intestinal ulcer,
  • a bleeding or blood-clotting disorder.

You may not be able to take aspirin and carisoprodol, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

It is not known whether aspirin and carisoprodol will be harmful to an unborn baby. Do not take aspirin and carisoprodol without first talking to your doctor if you are pregnant or could become pregnant during treatment.

It is not known whether aspirin and carisoprodol passes into breast milk. Do not take aspirin and carisoprodol without first talking to your doctor if you are breast-feeding a baby.

Aspirin and carisoprodol is not approved for use in children younger than 12 years of age. Also, do not use any medication that contains aspirin to treat a child or teenager who has a fever, flu symptoms, or chicken pox without first talking to a doctor. In children younger than 20 years of age, aspirin may increase the risk of Reye’s syndrome, a rare but often fatal condition.

How should I take aspirin and carisoprodol?

Take aspirin and carisoprodol exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water.

Do not take more of this medication than is prescribed. If the pain is not being adequately treated, talk to your doctor.

Store aspirin and carisoprodol at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication. Doses should be taken at least 4 hours apart.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of an aspirin and carisoprodol overdose include headache; ringing in the ears; dim vision; nausea; vomiting; diarrhea; sweating; increased thirst; low blood pressure (weakness, fainting, confusion); decreased breathing; and unconsciousness.

What should I avoid while taking aspirin and carisoprodol?

Use caution when driving, operating machinery, or performing other hazardous activities. Aspirin and carisoprodol may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking aspirin and carisoprodol. Also, in combination with aspirin, alcohol can be damaging to the stomach.

What are the possible side effects of aspirin and carisoprodol?

If you experience any of the following serious side effects, stop taking aspirin and carisoprodol and seek emergency medical attention or contact your doctor immediately:

  • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
  • paralysis (loss of feeling) or extreme weakness;
  • vision loss;
  • agitation or tremor;
  • red, black, or bloody stools; or
  • bloody vomit.

Other, less serious side effects may be more likely to occur. Continue to take aspirin and carisoprodol and talk to your doctor if you experience

  • drowsiness or dizziness;
  • headache;
  • depression;
  • blurred vision;
  • insomnia;
  • hiccups;
  • faint ringing in the ears; or
  • nausea or diarrhea.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect aspirin and carisoprodol?

Drowsiness or dizziness caused by carisoprodol may be increased by other drugs such as antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), other pain relievers, anxiety medicines, and muscle relaxants. Together, these medicines may cause dangerous sedation, possibly resulting in unconsciousness and death. Tell your doctor about all medicines that you are taking, and do not take any medicine without first talking to your doctor.

Do not take aspirin and carisoprodol without first talking to your doctor if you are taking any of the following medicines:

  • an anticoagulant such as warfarin (Coumadin), heparin, enoxaparin (Lovenox), dalteparin (Fragmin), danaparoid (Orgaran), ardeparin (Normiflo), or tinzaparin (Innohep);
  • a nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Motrin, Advil, Nuprin, others), ketoprofen (Orudis, Orudis KT, Oruvail), naproxen (Naprosyn, Anaprox, Aleve), diclofenac (Voltaren, Cataflam), nabumetone (Relafen), oxaprozin (Daypro), piroxicam (Feldene), etodolac (Lodine), fenoprofen (Nalfon), flurbiprofen (Ansaid), indomethacin (Indocin), ketorolac (Toradol), sulindac (Clinoril), or tolmetin (Tolectin); or
  • another salicylate such as aspirin (Acuprin, Ecotrin, Ascriptin, Bayer, others); choline salicylate and/or magnesium salicylate (Magan, Doan’s, Bayer Select Backache Pain Formula, Mobidin, Arthropan, Trilisate, Tricosal), or salsalate (Disalcid).

You may not be able to take aspirin and carisoprodol, or you may require a dosage adjustment or special monitoring if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with aspirin and carisoprodol. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

Your pharmacist has more information about aspirin and carisoprodol written for health professionals that you may read.

What does my medication look like?

Aspirin and carisoprodol is available with a prescription generically and under the brand name Soma Compound Tablets. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

  • Soma Compound Tablets (200 mg of carisoprodol and 325 mg of aspirin)–round, light-orange-and-white, two-layered tablets
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